“Treating Disease by Treating Mechanical Dysfunction”: A+Lecture in biology studies
The third lecture of the new edition of the “A+ Lectures” Programme took place on 16 November 2021, Tuesday.
The lecture titled “Treating Disease by Treating Mechanical Dysfunction” was delivered by Dr Ramaswamy Krishnan, Assistant Professor in Emergency Medicine, Harvard Medical School.
Dr. Krishnan is a bioengineer focused on discovery and treatment of respiratory problems of vital importance to emergency medicine. In sepsis and acute lung injury, he studies how the pulmonary endothelium acutely disrupts and dysfunctions. In asthma and COPD, he studies how the airways acutely narrow to impose breathing difficulties. He is also engaged in translating his basic science discoveries into new medications.
About the lecture:
While advances in gene sequencing, structural biology, and bioinformatics have provided crucial insights into disease processes, comparatively little is known about the mechanical aspects of disease. A critical impediment to progress has been the inability to quantify sub-cellular, cellular and tissue mechanics within the biological settings of human tissues, especially under pathological conditions.
To fill this gap, I will describe the development of innovative technologies and demonstrate its importance to treat airway constriction in asthma and cardiomyocyte dysfunction in arrhythmogenic cardiomyopathy.
Moderator: Professor Marek Łukasik, Vice Rector for Development and Cooperation, Pomeranian University in Słupsk.
The lecture is available online from our YouTube channel: